The 2021–22 Florida Gulf Coast Eagles women's basketball team represented Florida Gulf Coast University during the 2021–22 NCAA Division I women's basketball season.

The Eagles, led by twentieth-year head coach Karl Smesko, played their home games at the Alico Arena and were members of the Atlantic Sun Conference (ASUN).

They finished the season 30–3, 15–1 in ASUN play, to win the ASUN regular season.

They were the first seed in the ASUN tournament, and they defeated North Florida, Liberty and Jacksonville State to win the tournament championship and earn the conference's automatic berth in the NCAA tournament.

In the tournament, they defeated Virginia Tech before falling to Maryland in the second round to end their season.