The 2021–22 Illinois State Redbirds men's basketball team represented Illinois State University during the 2021–22 NCAA Division I men's basketball season.

The Redbirds played their home games at Doug Collins Court at Redbird Arena in Normal, Illinois as members of the Missouri Valley Conference.

They defeated Indiana State in the opening round of the MVC tournament before losing to Northern Iowa in the quarterfinals.

Twenty-six games into his tenth season as head coach, Dan Muller was notified by the school he would not be retained; however, the school stated he would be allowed to finish out the remainder of the season[1].

A day later, Muller announced that he would step aside immediately with associate head coach Brian Jones then being named interim coach for the remainder of the season[2].