The 2021–22 Jackson State Lady Tigers basketball team represented Jackson State University during the 2021–22 NCAA Division I women's basketball season.

The Tigers, led by fourth year head coach Tomekia Reed, played their home games at the Williams Assembly Center and were members of the Southwestern Athletic Conference (SWAC).

They received an automatic bid to the NCAA tournament and were the fourteen seed in the Spokane Regional.

As the first seed in the SWAC tournament they defeated Arkansas-Pine Bluff in the Quarterfinals, Southern in the Semifinal and Alabama State in the Final to win their second consecutive championship.

They received an automatic bid to the NCAA tournament and were the fifteen seed in the River Walk Regional.