The 2021–22 Louisiana Ragin' Cajuns women's basketball team represented the University of Louisiana at Lafayette during the 2021–22 NCAA Division I women's basketball season.

The Ragin' Cajuns, led by tenth-year head coach Garry Brodhead, played all home games at the Cajundome along with the Louisiana Ragin' Cajuns men's basketball team.

They made it to the 2020-21 Sun Belt Conference women's basketball tournament where the ultimately lost to Eastern Divisional champion Troy in the championship.

As conference regular season champion, the Cajuns were one of nine automatic bids to the 2021 WNIT.

They finished 0–2 in the tournament, where they were defeated by eventual Quarterfinalist Colorado in the first round and OVC regular season champs UT Martin in the consolation round.