The 2021–22 Middle Tennessee Blue Raiders men's basketball team represented Middle Tennessee State University during the 2021–22 NCAA Division I men's basketball season.

The team was led by fourth-year head coach Nick McDevitt, and played their home games at Murphy Center in Murfreesboro, Tennessee as members of Conference USA (C-USA).

In a season limited due to the ongoing COVID-19 pandemic, the Blue Raiders finished the 2021–22 season 5–18, 3–13 in C-USA play, to finish in sixth place in East Division.

[1] In the first round of the C-USA tournament, the Blue Raiders advanced to the second round when FIU was forced to withdraw due to positive COVID-19 tests.

[2] In the second round, they lost to North Texas.