The Panthers, led by fifth-year head coach Pat Baldwin, played their home games at the UW–Milwaukee Panther Arena as members of the Horizon League.

On March 2, 2022, the school fired head coach Pat Baldwin.

They lost in the semifinals of the Horizon League tournament to Cleveland State.

Sources: The Panthers were picked to finish in fourth place in the Horizon League in the coaches' poll, receiving two first-place votes and a total of 396 points.

Patrick Baldwin Jr. was selected to the Preseason First Team All-Horizon League, while DeAndre Gholston was selected to the Preseason Second Team All-Horizon League.