The 2021–22 Mount St. Mary's Mountaineers women's basketball team represented Mount St. Mary's University in the 2021–22 NCAA Division I women's basketball season.

The Mountaineers, led by first-year head coach Antoine White, played their home games at Knott Arena in Emmitsburg, Maryland as members of the Northeast Conference (NEC).

On May 2, 2022, it was announced that the Mountaineers will join the Metro Atlantic Athletic Conference (MAAC) on July 1, 2022, leaving the NEC where they had been members since 1989.

As the third seed in the NEC tournament they received a bye into the quarterfinals where they defeated St. Francis (PA).

Roster Last update: June 3, 2022 NEC COVID-19 policy provided that if a team could not play a conference game due to COVID-19 issues within its program, the game would be declared a forfeit and the other team would receive a conference win.