The 2021–22 Notre Dame Fighting Irish men's basketball team represented the University of Notre Dame during the 2021–22 NCAA Division I men's basketball season.

The Fighting Irish were led by 22nd-year head coach Mike Brey and played their home games at the Edmund P. Joyce Center in South Bend, Indiana as ninth-year members of the Atlantic Coast Conference.

2 seed, they lost in the quarterfinals of the ACC tournament to Virginia Tech.

11 seed in the West Region, where they defeated Rutgers in the First Four and then upset Alabama to advance to the Second Round where they lost to Texas Tech.

[1] In the ACC tournament they defeated Wake Forest[2] before losing to North Carolina in the second round.