The 2021–22 season was the 20th season in the existence of Oud-Heverlee Leuven and its second consecutive season in the top flight of Belgian football.

In addition to the domestic league, Oud-Heverlee Leuven participated in this season's edition of the Belgian Cup.

The following players were listed as part of Oud-Heveree Leuven's first team squad during the 2021–22 season, but never appeared on the match sheet Win Draw Loss Source: Soccerway

Source: Jupiler Pro League The league fixtures were announced on 8 June 2021.

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