Two teams left the league mid-season because of the Russian invasion of Ukraine.

A total of 10 teams from three countries contest the league, including eight sides from Russia, one from Belarus, and one from Kazakhstan.

[2] On 24 February 2022, Estonian club Kalev/Cramo terminated their membership in the VTB United League in protest against the Russian invasion of Ukraine.

[4] On 25 February, Polish club Zielona Góra also suspended their participation in the competition.

Quarterfinals, semifinals, and bronze medal series were played in a best-of-five format (2-2-1).