The 2021–22 Youngstown State Penguins men's basketball team represented Youngstown State University in the 2021–22 NCAA Division I men's basketball season.

The Penguins, led by fifth-year head coach Jerrod Calhoun, played their home games at the Beeghly Center in Youngstown, Ohio as members of the Horizon League.

They lost to Robert Morris in the first round of the Horizon League tournament.

[1] In a season limited due to the ongoing COVID-19 pandemic, the Penguins finished the 2020–21 season 15–12, 9–11 in Horizon League play, to finish in sixth place.

They defeated UIC in the first round of the Horizon League tournament before losing in the quarterfinals to Oakland.