[4] After being postponed to November the previous year due to the COVID-19 pandemic, the race returned to its traditional March date for 2021.
Originally, the 1000 Miles of Sebring, the FIA World Endurance Championship event run in conjunction with the 12 Hours in 2019, was slated to return, but was later cancelled due to international travel restrictions still imposed by the pandemic.
[8] Before the race, Filipe Albuquerque, Hélio Castroneves, Alexander Rossi, and Ricky Taylor led the DPi Drivers' Championship with 376 points, ahead of Jimmie Johnson, Kamui Kobayashi, Simon Pagenaud, and Mike Rockenfeller in second with 345 points.
[9] With 376 points, the GTD Drivers' Championship was led by Indy Dontje, Philip Ellis, Maro Engel, and Russell Ward.
[10] In DPi, Action Express Racing confirmed their #48 entry would contest the remaining Michelin Endurance Cup events.
[13][14] Dan Goldburg joined Mateo Llarena and Rasmus Lindh in the Performance Tech Motorsports entry.
[13] Matt Campbell and Mathieu Jaminet joined Cooper MacNeil in the WeatherTech Racing entry.
[17] Stephen Simpson subbed for Misha Goikhberg in the #19 GRT Grasser Racing Team entry.
[18] Michael de Quesada joined Daniel Morad and Billy Johnson in the Alegra Motorsports entry.
[19] Team Hardpoint EBM added a second entry featuring Earl Bamber,Trenton Estep, and Rob Ferriol.
3 Corvette of Jordan Taylor, whose 1:56.715 lap led Mathieu Jaminet's second-placed WeatherTech Porsche.
[25][26] Jensen led in LMP2 with a 1:50.224 lap in PR1's car, 0.456 seconds ahead of Tristan Nunez in WIN Autosport's second-placed No.
[28] Campbell's 1:56.891 lap led the GTLM class in WeatherTech Racing's Porsche, 0.573 seconds faster than Connor De Phillippi's No.
[27] GTD saw Mikaël Grenier's SunEnergy1 Mercedes-AMG record the fastest class lap: 2:01.111, 0.208 seconds faster than Foley's No.
Tim Zimmermann set the fastest time driving the #19 car for GRT Grasser Racing Team.
[34] Zacharie Robichon suffered an ABS failure on his #9 Porsche and touched the tire barrier at turn 13.
Pipo Derani took overall pole for the event driving the #31 car for Whelen Engineering Racing, besting Ricky Taylor in the WTR-Konica Minolta Acura entry.
[34] Jimmie Johnson, driving the #48 Ally Cadillac Racing entry, spun at turn 16 in the closing moments of the session and attempted to get one more lap in.
The result kept Filipe Albuquerque, Alexander Rossi, and Ricky Taylor atop the DPi Drivers' Championship with 688 points.
[44] As a result of winning the race, MacNeil advanced from sixth to second in the GTLM Drivers' Championship.
[44] As a result of winning the race, Long, Hindman, and Heylen advanced from fourth to first in the GTD Drivers' Championship.
Grenier and Habul dropped from second to fifth while Kern, Robichon, and Vanthoor advanced from eleventh to fourth.
PR1/Mathiasen Motorsports and CORE Autosport became the leaders of their respective class Teams' Championships with ten rounds remaining in the season.