The 2021 ANA Inspiration was the 50th ANA Inspiration golf tournament, held April 1–4, 2021 at the Dinah Shore Tournament Course of Mission Hills Country Club in Rancho Mirage, California.

Patty Tavatanakit won her first LPGA Tour event by two strokes over Lydia Ko.

Tavatanakit won the event wire-to-wire and became the first rookie to win the ANA Inspiration since Juli Inkster in 1984 and the fourth straight first-time major winner.

Top-80 on the previous year's season-ending LPGA Tour official money list 9.

Top-20 players plus ties on the current year LPGA Tour official money list at the end of the last official tournament prior to the current ANA Inspiration, not otherwise qualified above, provided such players are within the top-80 positions on the current year LPGA Tour official money list at the beginning of the tournament competition 12.