The 2021 Adriatica Ionica Race/Sulle Rotte della Serenissima was a road cycling stage race that took place between 15 and 17 June 2021 in the northeastern Italy.

[1] It was the third edition of the Adriatica Ionica Race and a category 2.1 event on the 2021 UCI Europe Tour.

[2] After the 2020 edition was cancelled due to the COVID-19 pandemic, the race made its return in 2021, though it was forced to downscale to three stages from the usual five.

[8] The first stage, in Friuli-Venezia Giulia, headed west from Trieste, with a slightly undulating route and one categorized climb on the way to Aviano.

[10] The second and queen stage sees the race continue heading west, from Vittorio Veneto in the Veneto region, with a summit finish atop the Cima Grappa at 1,712 metres (5,617 ft) above sea level.