The 2021 Albany Great Danes football team represented the University at Albany, SUNY as a member of the Colonial Athletic Association (CAA) during the 2021 NCAA Division I FCS football season.

Led by eighth-year head coach Greg Gattuso, the Great Danes compiled an overall record of 2–9 with a mark of 1–7 in conference play, placing last out of 12 teams in the CAA.

The team played home games at Bob Ford Field at Tom & Mary Casey Stadium in Albany, New York.

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