[5][6][7] In addition, four Razorbacks – Moore, Franklin, catcher Casey Opitz, and designated hitter Matt Goodheart – were named to the SEC Baseball Coaches preseason All-Conference first team.

[13] Zebulon Vermillion and Patrick Monteverde started on the mound for the Razorbacks and Red Raiders, respectively, and both pitchers carried their teams through four scoreless innings to begin the game.

Arkansas tied the game in the sixth after Jalen Battles' 2 RBI double, a wild pitch, and a Robert Moore sac fly, though Tech pulled one back to enter the seventh inning up by a single run.

In the bottom of the sixth, following a Robert Moore groundout, the Hogs got two runners on base by way of a six-pitch walk to Christian Franklin and Cullen Smith being hit with a pitch, prompting Texas to pull Stevens in favor of Dawson Merryman.

After striking out the first batter he faced, Merryman gave up a three-run home run to Brady Slavens, which increased Arkansas' lead to four.

[18] Caleb Bolden, credited with 4 innings pitched with no hits given up, was awarded the save; Caden Monke got the win and Texas starter Tristan Stevens was handed the loss.

[19] While starter Peyton Pallette did not get a decision, he finished with a career-best eight strikeouts, with the Hogs pitching staff combining for fifteen in what was the first shutout of Texas since 1988.

[21] Lael Lockhart, a graduate transfer from Houston, made his debut as the Hogs' starter, while Austin Krob started on the mound for TCU.

With the exception of the four-pitch walk dealt to TCU's Tommy Sacco, neither offense managed a baserunner in the first inning, and the Hogs recorded a hit but could not score in the top of the second.

With the score still 1–0 in favor of TCU, Jaxon Wiggins made his Razorback debut when he entered the game for Taylor to begin the bottom of the sixth; he retired his first three batters consecutively on strikeouts.

The Razorbacks again made a pitching change to begin the seventh inning, sending Ryan Costeiu out, who, like Wiggins, retired the first three batters he faced.

After six scoreless innings, Arkansas found the scoreboard in the seventh, as a Christian Franklin triple drove home Jalen Battles to tie the game.

Immediately afterwards, King was pulled and Haylen Green was sent to the mound for TCU, though Cullen Smith singled shortly thereafter to drive home the go-ahead run for the Razorbacks.

[23] The Razorbacks opened their 2021 home season at Baum–Walker Stadium in Fayetteville with a four-game weekend series against the Southeast Missouri State Redhawks, who entered with a 2–1 record.

Inheriting loaded bases, Wicklander forced a fielder's choice that scored the Redhawks' second run, and a steal of home put SEMO up by three after the top of the first.

Trailing 2–5, Arkansas needed three runs in the final half-inning to avoid a loss in their home opener; a pair of singles set up an RBI for Jalen Battles that brought the game within two.

After a pitching change that sent Kyle Miller to the mound, a bases-loaded walk to Franklin and a sac fly from Cullen Smith, tied the game at five.

A double and a walk by Casey Opitz and Cayden Wallace, respectively, prompted a pitching change that brought Blake Cisneros into the game, though he hit his first batter to load the bases.

Both teams found the scoreboard in their respective halves of the third inning, as SEMO scored two by way of a walk and a pair of singles, while the Razorbacks put up two of their own via a Robert Moore two-run homer.

A 1-2-3 second inning for the Redhawks allowed the Hogs offense to take the field once again, where a leadoff single from Robert Moore was immediately followed by a first-pitch two-run homer by Christian Franklin, his third of the series, bumping the Razorbacks' lead to six.

Despite tallying their third hit, SEMO was unable to score, and they brought in their fourth pitcher of the game, Joey Kossine, to start the bottom of the fifth, the first scoreless frame for the Arkansas offense.

For the first time in the game, Arkansas was retired in order in the bottom of the sixth, as were the Redhawks in the top of the seventh, with Kole Ramage starting that inning on the mound.

Two hits in the seventh for Arkansas proved fruitless, and SEMO managed to cut the deficit to seven with an eighth inning solo home run, off the bat of Andrew Keck.

In the final inning, Gabriel Starks, also making his first collegiate appearance,[33] came to the mound for Arkansas, and retired the side to end the game, 9–3, and clinch the series for the Razorbacks.

[35] Looking to complete the season-opening series sweep, Arkansas and Southeast Missouri State met for a fourth and final time on Sunday afternoon in Fayetteville.

A Casey Opitz double and a Jalen Battles RBI single several batters later increased the lead to three, and was the end of the afternoon for Williams as Connery O'Donnell came in to relieve him after 1.2 innings.

SEMO kept up the offense in their half of the fourth inning, as Andrew Keck and Mason got onboard and were driven home by a single from Ty Stauss, which prompted Arkansas's first pitching change of the afternoon, a switch to Caden Monke.

Later in the inning, Arkansas increased the lead further; Bates and Battles plated runs on consecutive RBI base hits, making the score 11–3 in the Razorbacks' favor.

Both offenses were relatively quiet from then until the bottom of the sixth inning, when Robert Moore's home run scored himself and Jalen Battles and made it a one-run game again.

Ryan Costeiu entered the game to pitch the eighth inning for Arkansas, and walked two batters before being replaced in favor of Kevin Kopps.