On March 5, 2021, Holy Cross withdrew from the tournament due to a positive COVID test.
In the first round, after the withdrawal of Holy Cross, the two lowest-seeded teams from each region, as determined by the conference regular season standings, played a single game with the winners advancing to the quarterfinals.
The top six teams from the conference regular season standings received byes to the quarterfinals.
In the semifinals, the highest remaining seed of each region will play the lower remaining seed of the opposite region in single games, with the winners advancing to the championship game.
[2] Teams are reseeded for the semifinals Note: * denotes overtime period(s) Bentley withdrew from the tournament due to an increase of COVID-19 positive tests on campus.