The Cougars were led by sixth-year head coach Kalani Sitake and played their home games at LaVell Edwards Stadium.

Quarterback Zach Wilson, offensive lineman Brady Christensen, and wide receiver Dax Milne all opted to forego their senior seasons and leave early for the NFL Draft.

Christensen was selected in the third round by the Carolina Panthers, while Milne and two seniors, nose tackle Khyiris Tonga and defensive back Chris Wilcox, were each selected in the seventh round by the Washington Football Team, Chicago Bears, and Tampa Bay Buccaneers, respectively.

On January 4, 2021 it was announced that Jeff Grimes had accepted a job with Baylor University as the offensive coordinator.

The NuSkin BYU Sports Network is owned and operated by BYU Radio and features the talents of Greg Wrubell (play-by-play), Riley Nelson (analyst), Mitchell Juergens (reporter/sideline analyst), and Jason Shepherd (host) for the third consecutive year, with Ben Bagley subbing in for Jason Shepherd when he has women's soccer or men's basketball broadcasts.