The 2021 Big South women's basketball tournament was the postseason women's basketball tournament that ended the 2020–21 season of the Big South Conference.
The first round will be played at campus sites at the home of the higher seed.
The championship game will be held at the home arena of the higher surviving seed.
Hampton cancelled their season after going 4-11,[1] and Radford wasn't able to have the required number of players, so they will not compete in the conference tournament.
This season, the team seeds were determined firstly by record (75%) within the conference and then by a "ranking index formula" (RIF) developed by the Big South for those teams affected by pauses in their schedules due to COVID-19 (25%).