The 2021 CS Lombardia Trophy Memorial Anna Grandolfi was held on September 10–12, 2021 in Bergamo, Italy.

[1] It was part of the 2021–22 ISU Challenger Series.

[2] Medals were awarded in the disciplines of men's singles, women's singles, and ice dance.

The International Skating Union published the list of entries on August 18, 2021.