The 2021 Gran Premio d'Italia was the third event of the 2021–22 ISU Grand Prix of Figure Skating: a senior-level international invitational competition series.

Skaters earned points toward qualifying for the 2021–22 Grand Prix Final.

On August 27, 2021, the International Skating Union announced that the Gran Premio d'Italia would replace the Cup of China, which was cancelled on August 16 due to travel restrictions and quarantine requirements related to the COVID-19 pandemic.

In addition to the successful bid from the Federazione Italiana Sport del Ghiaccio, the ISU received applications from the Hungarian Skating Federation and U.S.

[3] The Gran Premio d'Italia assignments were updated on September 10; the Chinese Skating Association's host spots were reallocated to the Federazione Italiana Sport del Ghiaccio.