The 2021 Canadian Mixed Doubles Curling Championship (branded as the 2021 Home Hardware Canadian Mixed Doubles Curling Championship for sponsorship reasons) was held from March 18 to 25 at the Markin MacPhail Centre at Canada Olympic Park in Calgary, Alberta.

[4] In addition, due to COVID-19 restrictions and logistics, most provincial playdowns have been cancelled, with teams being selected by their respective member associations.

During the night of Sunday, March 21, Darren Moulding was experiencing back spasms, forcing him and partner Joanne Courtney to forfeit their match the next morning.

Each player was ranked based on their top three CTRS events during the 2019–20 season.

Both players must also be part of Curling Canada's National Team program.