The 2021 Central Connecticut Blue Devils football team represented Central Connecticut State University as a member of the Northeast Conference (NEC) during the 2021 NCAA Division I FCS football season.

The Blue Devils, led by third-year head coach Ryan McCarthy, played their home games at Arute Field.

Central Connecticut compiled an overall record of 4–7 with a mark of 4–3 in conference play, tying for fourth place in the NEC.

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