The 2021 NCAA Division I FCS football season, part of college football in the United States, was organized by the National Collegiate Athletic Association (NCAA) at the Division I Football Championship Subdivision (FCS) level.

The season ended with a single-elimination tournament, with the championship game held on January 8, 2022 at Toyota Stadium in Frisco, Texas.

20 Washington 7 September 4: East Tennessee State 23, Vanderbilt 3 September 11: Duquesne 28, Ohio 26 September 11: Jacksonville State 20, Florida State 17 September 18: Incarnate Word 42, Texas State 34 September 18: Northern Arizona 21, Arizona 19 November 6: Rhode Island 35, UMass 22 November 13: Maine 35, UMass 10 After the prior season's playoffs were reduced to a 16-team bracket, FCS returned to a 24-team bracket for this season: 11 of the teams were decided via automatic bids issued to conference champions (listed above) and 13 teams were determined via at-large bids; the top eight teams were seeded.

[8] Source:[11] The top 25 from the Stats Perform and USA Today Coaches Polls.

The regular season began with three games on Saturday, August 28: Rankings reflect the Stats Perform Poll.