By winning the American League Central, it secured the team their first back-to-back postseason appearance in franchise history after having clinched a wild card berth in the previous season.

[1] On October 29, 2020, the White Sox announced that they would hire Tony La Russa, who managed the team from 1979 to 1986.

La Russa had not managed a team since the 2011 St. Louis Cardinals who won the World Series that year.

† Minimum 3.1 plate appearances per team games played AVG qualified batters: Abreu, Anderson, Moncada, Vaughn

‡ Minimum 1 inning pitched per team games played ERA & WHIP qualified pitchers: Cease, Giolito, Keuchel Source: MLB Standings Grid – 2021 Updated with the results of all games through October 3, 2021.

[32] Hendriks later earned AL Reliever of the Month honors again for September/October after going 8-for-8 in save opportunities while only allowing six hits, no walks, and striking out 21 batters in 13 2/3 innings.