The 2021 Coastal Carolina Chanticleers football team represented Coastal Carolina University as a member of the East Division of the Sun Belt Conference during the 2021 NCAA Division I FBS football season.

Led by fourth-year head coach Jamey Chadwell, the Chanticleers compiled an overall record of 11–2 with a mark of 6–2 in conference play, tying for second place in the Sun Belt's East Division.

Coastal Carolina was invited to the Cure Bowl, where the Chanticleers defeated Northern Illinois.

The Chanticleers were picked to finish tied for first in the East Division and second overall in the conference.

The Chants hosted three of their four non-conference opponents at Brooks Stadium: The Citadel, from the NCAA Division I FCS Southern Conference; Kansas of the Big 12 Conference; and UMass, an FBS Independent.