The 2021 Coastal Carolina Chanticleers softball team represented Coastal Carolina University during the 2020 NCAA Division I softball season.

The Chanticleers played their home games at St. John Stadium – Charles Wade-John Lott Field.

The Chanticleers were led by twelfth-year head coach Kelley Green and were members of the Sun Belt Conference.

The Sun Belt Conference Coaches Poll was released on February 8, 2021.

Coastal Carolina was picked to finish fourth in the Sun Belt Conference with 68 votes.