The 2021 South Alabama Jaguars softball team represented the University of South Alabama during the 2021 NCAA Division I softball season.

The Jaguars were led by fifteenth-year head coach Becky Clark and were members of the Sun Belt Conference.

The Sun Belt Conference Coaches Poll was released on February 8, 2021.

South Alabama was picked to finish eighth in the Sun Belt Conference with 36 votes.

[2] [3] Pitchers Outfielders Catchers Infielders Utilitys *Rankings are based on the team's current ranking in the NFCA/USA Softball poll.