[1][2] Deportivo Cali won their first title in the competition, defeating the defending champions Santa Fe in the double-legged final series by a 6–3 aggregate score.
[3] On 29 April 2021, the División Mayor del Fútbol Profesional Colombiano (DIMAYOR) confirmed the format for the 2021 Liga Femenina season, following a meeting of its Board of Competition.
For this season the league would have 12 teams competing, which were split into three groups of four where they would play each other in a double round-robin tournament.
Out of the 13 clubs that competed in the previous season, neither Deportivo Pasto nor Junior fielded a team in this edition, whilst Cortuluá were to return to the competition.
[1] However, on 8 June 2021 Cortuluá withdrew from the competition owing to financial reasons, with which the number of participant clubs went down to 11.