[1] The competition, which is usually played in January prior to the start of each Categoría Primera A season, was delayed to October 2021 due to the schedule saturation of both involved sides and a lack of available dates in early 2021.
[2] Santa Fe beat América de Cali by a 5–3 aggregate score to win its fourth Superliga Colombiana title.
[3] Due to the COVID-19 pandemic in Colombia causing the curtailing of the 2020 Categoría Primera A season which only had one champion instead of the usual two, DIMAYOR confirmed that the competition would also be contested by the best ranked team in the aggregate table of the 2020 season, Santa Fe, in addition to the league champions América de Cali.
[4] Assistant referees:[5] Elkin Echavarría Javier Zemanate Fourth official: Yahir Cárdenas
Match rules[6] Assistant referees:[7] John León Mario Tarache Fourth official: Luis Matorel