They split or lost 16 consecutive road series between September 2020 and July 2021, a new low for a team thought by writers to have had a disadvantage when playing in lower altitude when away from Coors Field since its inception.

[4] On October 28, 2020, the Rockies declined the 2021 option on Daniel Murphy's contract, and Drew Butera, Matt Kemp, Chris Owings, Kevin Pillar, and A. J. Ramos declared free agency.

[10] Jairo Díaz was designated for assignment on April 1, 2021 to make room for Jhoulys Chacín ahead of Opening Day.

[11] The Rockies signed pitcher Dereck Rodríguez to a minor league deal with an invitation to spring training on November 9, 2020.

[14] On February 11, 2021, the Rockies signed infielder Greg Bird to a minor league deal with an invitation to spring training.

[10] On April 1, 2021, the Rockies signed Jhoulys Chacín to a major league contract ahead of their first game on Opening Day.