Due to the COVID-19 pandemic, Old Dominion did not play the 2020 season, leaving the conference with 13 participating teams.

[2] The rest of the conference played the full season, with some games postponed or cancelled for reasons relating to the pandemic.

In the 2020 Conference USA Football Championship Game, the Blazers defeated the Thundering Herd 22–13.

Doc Holliday was released from the Head Coach position at Marshall after 11 seasons with the program.

He was replaced by Charles Huff, who had previously been the running backs coach at Alabama.

[23] Will Hall took over as the new permanent Head Coach at Southern Miss, filling the vacancy left after Jay Hopson had resigned one game into the previous season.

The following individuals received postseason honors as voted by the Conference USA football coaches at the end of the season.

Currently, the NCAA compiles consensus all-America teams in the sports of Division I-FBS football and Division I men's basketball using a point system computed from All-America teams named by coaches associations or media sources.

Honorable mention and fourth team or lower recognitions are not accorded any points.