All matches were played at the PFF National Training Center in Carmona, Cavite.
[1] There were initially plans to hold the cup tournament earlier in the year, but it was cancelled in March 2021 (along with several postponements to the 2021 Philippines Football League).
[2][1] The tournament was revived once again in October 2021, after the league season was cancelled,[3][4] and now scheduled to take place during November 7–19.
[5] United City withdrew after the draw due to an undisclosed legal dispute filed against the club when it was still Ceres–Negros and under a different management.
[11] Kaya–Iloilo, Mendiola and Stallion Laguna are eligible to qualify as holders of an AFC club license.