The 2021 Peru Cup season (Spanish: Copa Perú 2021), the largest amateur tournament of Peruvian football.

The Regional Stage (Spanish: Etapa Regional) starts in October, and the National Stage (Spanish: Etapa Nacional) starts in November.

The following list shows the teams that qualified for the Regional Stage.

The round was played on 10 October 2021, in a single knock-out match format.

The round was played on 14 October 2021, in a single knock-out match format.