2021 Cornwall-Meadowbank provincial by-election

[3] MacDonald had held the seat since 2015 but resigned to run for Member of Parliament in the 2021 Canadian federal election in Malpeque, which he was successful.

Mark McLane of the governing Progressive Conservatives won the seat, defeating Liberal Jane MacIsaac.

[1] Musician and activist Todd MacLean ran unopposed for the Green Party nomination, and was acclaimed on October 4.

[5] Party president Charles Blue had indicated that several potential candidates were interested in the nomination,[4] however McLane ran unopposed.

Businesswoman Jane MacIsaac won the Liberal nomination from a field of four candidates, and biology professor Larry Hale was acclaimed for the New Democrats.