The Women's 50 metre breaststroke competition of the 2021 FINA World Swimming Championships (25 m) was held on 16 and 17 December 2021.

[1] Prior to the competition, the existing world and championship records were as follows.

The heats were started on 16 December at 10:41.

[2] The swim-off was held on 16 December at 12:42.

[4] The final was held on 17 December at 18:42.