The 2021 Jacksonville State Gamecocks football team represented Jacksonville State University in the 2021 NCAA Division I FCS football season.

Maxwell Thurmond was appointed interim head coach for the final two games of the year.

Jacksonville State finished the season with an overall record of 5–6 and a mark of 3–3 in conference play, tying for fourth place in the AQ7.

The team played home games at Burgess–Snow Field at JSU Stadium in Jacksonville, Alabama.

This college football 2020s season article is a stub.