The 34th Annual Nickelodeon Kids' Choice Awards ceremony was held on March 13, 2021, at the Barker Hangar in Santa Monica, California[a] with Kenan Thompson serving as host.

[4] The ceremony was held with most presenters, winners, and performers in-person, with some appearing virtually due to the ongoing COVID-19 pandemic.

Justin Bieber performed "Intentions" with Quavo, as well as "Anyone" and "Hold On", the former originally being planned for the previous years' ceremony.

[10] The ceremony featured appearances by celebrities including Anthony Anderson, Iain Armitage, Jayden Bartels, Joshua Bassett, Hailey Bieber, Millie Bobby Brown, BTS, Dove Cameron, Terry Crews, Charli D'Amelio, David Dobrik, Robert Downey Jr., Young Dylan, Gal Gadot, Jennifer Garner, Gabrielle Nevaeh Green, Tiffany Haddish, Kim Kardashian, Anna Kendrick, Heidi Klum, Liza Koshy, That Girl Lay Lay, Jules LeBlanc, Darci Lynne, Marsai Martin, Gaten Matarazzo, Lin-Manuel Miranda, Tyler Perry, Addison Rae, Noah Schnapp, JoJo Siwa, Sofía Vergara, and Finn Wolfhard.

Also during the show were iCarly cast members Miranda Cosgrove, Nathan Kress, and Jerry Trainor all reuniting together, and Thompson's onscreen daughters of Kenan, Dani and Dannah Lane.