Following an interception by Rams cornerback David Long Jr. on the game's opening drive, Stafford's first scoring toss came on L.A.'s third offensive play, as he found wide receiver Van Jefferson on a deep pass down the middle.

But Indianapolis vaulted back in the lead 21–17 at the beginning of the fourth quarter when a bad punt snap resulted in a fumble recovery by Ashton Dulin in the end zone for a touchdown.

Matt Gay's 42-yard field goal ended L.A.'s opening drive, and wide receiver Van Jefferson caught a 14-yard touchdown pass from Matthew Stafford for the early advantage.

Trailing 7–3 at halftime, the Rams stormed back with a dominant second half performance to defeat the host Seahawks in a Thursday Night Football matchup.

Facing his former team for the first time, quarterback Matthew Stafford completed 28 of 41 passes for 334 yards and three touchdowns to rally Los Angeles over the winless Lions, who took a 10–0 lead in the first quarter.

Rolling to their seventh win in eight weeks, the Rams scored 38 unanswered points through three quarters in defeating the host Texans for the fourth time in five all-time meetings.

Visiting Tennessee went ahead for good early in the second quarter on tight end Geoff Swaim's 2-yard touchdown reception from quarterback Ryan Tannehill.

On the very next play from scrimmage, Stafford attempted to evade a pass rush in his own end zone, and his errant toss was intercepted by Titans free safety Kevin Byard, who returned it 24 yards for a touchdown.

Crosby hit another field goal which was then matched by Rams kicker Matt Gay and Stafford threw a 6-yard TD pass to running back Darrell Henderson with 1:28 remaining in the first half to close within 20–17.

Linebacker Ernest Jones lead the Rams with nine tackles, including a shared sack with Leonard Floyd, while Jalen Ramsey and Taylor Rapp had one fumble recovery each in L.A.'s rout in what would be the team's largest margin of victory for the season.

Despite going in with a depleted lineup that was missing six starters (including cornerback Jalen Ramsey and tight end Tyler Higbee) due to an outbreak of COVID-19, the Rams came up with big plays to thwart the host Cardinals at State Farm Stadium with a 30–23 victory on Monday Night Football that opened up the NFC West title race.

In a game that was postponed for two days due to COVID-19 concerns, the Rams surged ahead in the second half to defeat the NFC West rival Seahawks at SoFi Stadium for their third straight victory.

Following an exchange of punts, Seattle drove to midfield but was stopped on downs, and Michel had a 17-yard run to set up Gay's second field goal of the game, this time from 35 yards with 1:51 remaining.

Clark intercepted Stafford a second time on the next drive to end a Rams scoring threat, and the Ravens drove 91 yards in 15 plays but were held to a Justin Tucker field goal.

The Ravens drove inside the Rams 10 on their next drive, but Aaron Donald and Leonard Floyd combined for a sack of Huntley that forced Baltimore to settle for a fourth field goal by Tucker with 4:30 remaining.

Starting from his own 25, Stafford led the Rams' comeback by completing five straight passes, including a critical fourth down-and-5 catch by Beckham to keep the drive alive with just over a minute remaining.

Los Angeles built its first half advantage thanks to kicker Matt Gay's 43-yard field goal in the first quarter and two touchdown receptions by tight end Tyler Higbee from quarterback Matthew Stafford.

The Rams turned the tide in the fourth quarter when cornerback Jalen Ramsey made an acrobatic interception of Jimmy Garoppolo in the end zone, which sparked a 92-yard touchdown drive.

But after the teams traded punts, the Rams were unable to stop the 49ers as Garoppolo threw a 14-yard touchdown pass to Jennings with 26 seconds left that (following a Gould PAT) tied the game.

With under two minutes left, the Rams drove to near midfield but Stafford's final pass intended for Odell Beckham Jr. was intercepted by 49ers cornerback Ambry Thomas to end the game.

Facing third-and-7 from the Arizona 4, Murray tried to evade Rams linebacker Troy Reeder and as he fell threw a desperation pass that was easily picked off at the 3-yard-line by cornerback David Long Jr. and resulted in the shortest interception return for a touchdown in NFL playoff history.

Los Angeles built a 27–3 lead over the defending Super Bowl champions before Tampa Bay rallied to score 24 unanswered points to tie the game with 42 seconds remaining.

After the Buccaneers added a field goal, a fumble by Kupp on the Rams' next possession was recovered by Tampa Bay, leading to a 1-yard touchdown by running back Leonard Fournette.

Rallying from a 10-point deficit at the start of the fourth quarter, the Los Angeles Rams overcame the rival San Francisco 49ers 20–17 to win the NFC Championship Game for the second time in four seasons.

The Rams' defense was effective in neutralizing San Francisco's running game, allowing just 50 yards on the ground for the night and forced a punt at midfield on the next drive.

Stafford connected twice with wide receiver Odell Beckham Jr. on key receptions to set up a 40-yard field goal by kicker Matt Gay to tie the score at 17–17 with 6:53 remaining.

Cornerback Jalen Ramsey fell down after making contact with Bengals wide receiver Tee Higgins, who caught a 75-yard touchdown pass from quarterback Joe Burrow.

Then on L.A.'s first offensive play of the second half, a Stafford pass bounced off the hands of backup wide receiver Ben Skowronek and was intercepted, giving Cincinnati possession at the Rams 31.

Stafford failed to connect on three straight passes, but a pair of penalties on Cincinnati helped to keep the drive alive and the Rams found themselves with a first-and-goal at the Bengals 1 with 1:35 remaining.

But following an incomplete pass on second down, Donald fought off Bengals guard Hakeem Adeniji with his right arm and reached around with his left to stop running back Samaje Perine for no gain to set up a 4th-and-1 play.