The defending champions were Johor Darul Ta'zim, who won it in the 2019 edition, as the 2020 edition was cancelled midway during the tournament due to the COVID-19 pandemic in Malaysia.
In the final, they lost 2–0 to Kuala Lumpur City, who won their fourth title.
As winners, Kuala Lumpur City qualified for the 2022 AFC Cup.
In the competition, the top eleven teams from the 2021 Malaysia Super League were joined by the top five teams from the 2021 Malaysia Premier League.
The final was played at the Bukit Jalil National Stadium in Kuala Lumpur on 30 November 2021.