Prior to the campaigning period, 25 state governors signed an agreement with President Andrés Manuel López Obrador, which stated that they would maintain neutrality during the elections, uphold the people's free will, reject funding from organized crime, and abstain from utilizing official funds to back specific candidates or parties.

[5] The Sinaloa Cartel exercises considerable control in the northwest while the Jalisco New Generation Cartel′s (CJNG) influence is in the west, including the states of Michoacan and Guerrero.

[6] Election-related violence is of particular concern in Michoacan, not only because of the aforementioned drug cartels but also because of armed community police who often act as vigilantes.

[6] During the campaigning period, 91 candidates were assassinated,[2] where 80% of the cases involved individuals who belonged to a party that did not control the state government.

[8] The Instituto Nacional Electoral (INE) canceled the registration of 19 candidates of MORENA for failure to report pre-campaign expenses.

[9] The INE canceled the registration of 49 candidates affiliated with MORENA for failing to report expenses related to their pre-electoral campaigns, which affected two gubernatorial, 25 federal deputies, six local deputies, twelve municipal presidents, and four borough president candidates.

Two candidates for federal deputy and one for governor of Michoacan from the Michoacán a Redes Sociales Progresistas were also withdrawn.

Fines were also imposed on PRD (MXN $409,031), MC ($227,886), independents ($182,361), PES ($98,782), Redes Sociales Progresistas ($85,229), PAN ($26,845), and PVEM ($1,476).

[10] The FGR (Federal Elections Prosecutor) is investigating about 80 complaints about Internet celebrities (Spanish: influencers) who illegally used social media to sway votes toward the PVEM.

[11] The INE said that 300 polling places could not be installed in Chiapas, Michoacán or Oaxaca due to social conditions that make voting dangerous or impossible.

[12] Daniel Serrano, candidate (MORENA) for municipal president in Cuautitlán Izcalli, complained about vote buying on election day.

[13] The Instituto Electoral del Estado de México (IEEM) says that irregularities and violence on election day in Nextlalpan, State of Mexico, make it impossible to give a preliminary vote count (PREP), it may be necessary to hold another election.

[14] Violence was reported in Amecameca,[15] Metepec,[16] Naucalpan,[17] Nextlalpan,[14] and Valle de Chalco.

[1] Before the elections, on March 4, 2021, Yuriel Armando González Lara, mayoral candidate for Nuevo Casas Grandes, was assassinated.

[1] On March 31, 2021, Alejandro Galicia Juárez, candidate for regidor of Apaseo el Grande, was assassinated.

[1] Organized crime and indigenous groups blocked the installion of 100 of the 6,251 polling places in the state.

[17] In Valle de Chalco, two polling stations were attacked by armed gunmen, causing their early closure.

[1] The National Electoral Institute (INE) warned that Governor Antonio Echevarria was evading his responsibilities, claiming that he lied about the state not having MXN $200 million needed to organize the elections.

Additionally, 800 ballots were stolen in “El Ocote” y San José Llano Grande, Miahuatlán de Porfirio Díaz.

[1] On March 4, 2021, Melquiades Vázquez Lucas, mayoral candidate for La Perla, was assassinated.