[5] On 13 April 2021 the INE cancelled the registrations of Manuel Guillermo Chapman (Morena), Ana Elizabeth Ayala Leyva, (Juntos Haremos Historia), and Raúl Tadeo Nava (Labor Party) for failure to certify their lack of involvement in gender violence.

[6] On 3 June, the INE warned about possible sanctions on Catholic bishops, in particular Juan Sandoval Íñiguez, for their interference in the elections.

[8][9] Several electoral events in 2020 were disrupted by the ongoing COVID-19 pandemic, leading to the postponement of the 2020 local elections from 7 June to 18 October.

[10][11] The National Electoral Institute (INE) implemented health protocols to mitigate the spread of the virus, which it later deemed successful.

[18][19] In June 2020, Alfonso Ramírez Cuéllar, president of the National Regeneration Movement (Morena), announced an alliance with the Labor Party (PT), and the Ecologist Green Party of Mexico (PVEM), expressing full support for Andrés Manuel López Obrador's legislative agenda.

[26] Citizens' Movement (MC) announced that they would not form an alliance with the PAN and PRD, as they had in 2018, and would instead contest the election independently, citing disagreements with the parties.

In a speech on 14 June, President Andrés Manuel López Obrador said "We must celebrate it, because we achieved our purpose: to establish in Mexico an authentic, a true democracy.

[56] The ruling coalition, Juntos Hacemos Historia, retained a 27-seat majority in the Chamber of Deputies with about 44% of the vote, but lost a significant number of seats, resulting in the loss of the two-thirds supermajority it held during the LXIV Legislature.

[57] Many commentators saw the election as an electoral stalemate for President Andrés Manuel López Obrador, as the ruling coalition only achieved a majority and not his desired two-thirds supermajority.

[57] At around midnight Mexico City time, the INE published its official quick count, declaring that Juntos Hacemos Historia retained a majority in the Chamber of Deputies.

[61] Due to the annulment of ballot boxes in certain districts, the results in some constituencies changed, with Juntos Hacemos Historia losing three seats and Va por México gaining three.