The 2021 Monaco Formula 2 round was a couple of motor races for Formula 2 cars that took place on 21–22 May 2021 at the Circuit de Monaco in Monte Carlo, Monaco as part of the FIA Formula 2 Championship.

It was the second round of the 2021 FIA Formula 2 Championship and ran in support of the 2021 Monaco Grand Prix.

By winning the Feature Race in the principality, Théo Pourchaire thus became the youngest race winner in Formula 2 history aged 17 years and 264 days, beating the previous record of Lando Norris.

[1] Jack Aitken returned to Formula 2 as a replacement for Matteo Nannini for HWA Racelab, who decided to fully concentrate on his campaign in Formula 3 due to sponsorship issues.