[1] Singer Iza and television presenter Tatá Werneck hosted the show.

The nominees for Duo of the Year were announced on 16 October 2021, on the Altas Horas.

[5][6] Anitta led the nominations with five, followed by Luísa Sonza and Marina Sena with four each, while Israel & Rodolffo, João Gomes, and Luan Santana received three nominations each.

[7] On 7 November 2021, it was announced that the category Female Singer of the Year had its voting canceled.

The winners of the following categories were chosen by Multishow Award Academy.