The 2021 NCAA Men's Water Polo Championship occurred from December 4–5, 2021 in Los Angeles, California at the Spieker Aquatics Center.

[1] The championship featured a knockout format where schools that lost were eliminated from the tournament.

The championship pairings were announced on Sunday, November 21, 2021 by the NCAA Men’s Water Polo Committee.

Top ranked teams from five conferences received automatic qualification (AQ).

The two at-large teams, without geographical restrictions, came from MPSF: UCLA and Southern California.