2021 NCAA Division I women's volleyball tournament

Wisconsin won its first NCAA national championship by defeating Big Ten rival Nebraska 3–2.

Louisville, having gone a perfect 28–0 in the regular season, earned the first number one overall seed in conference history.

Both teams utilized their home court advantages to earn their respective first trips to the national semifinals.

While the ACC made history in the semifinals, the Cardinals and Panthers were joined by Wisconsin and Nebraska out of the Big Ten.

This tournament marked the fourteenth straight year that at least one member of the Big Ten reached the semifinal.

The first two rounds, normally referred to as the subregionals, will be played at the sites of the top 16 seeds, replicating the format done in the basketball tournaments.