The champions directly qualify for the 2022 Basketball Africa League season.
DUC Dakar won its fifth national championship after defeating defending champions AS Douanes in the final.
[1] Thierno Niang was named the league's Finals MVP.
[2] Tamba and HLM were relegated after finishing in the last two places in the 2019 Nationale 1 season.
Bopp and ISEG Sports were promoted.