On December 9, 2021, the BAL announced a new format for the season, with an expansion of the number of total games to 38.

The Angolan FAB had abandoned the season due to the COVID-19 pandemic and awarded the team the place without naming it as champions.

On January 14, 2022, FIBA Africa decided to exclude the Rivers Hoopers as it stated that the Nigeria Basketball Federation failed to organise a national championship.

[12] The BAL chose to give AS Salé direct qualification to replace the Nigerian team.

REG qualified directly for the regular season as Rwanda hosted the playoffs and finals.

Each team also featured one player from the NBA Academy Africa, under the new BAL Elevate program.

The qualifying tournaments started on 21 October 2021 and ended on 16 December 2021, with 23 teams from 23 countries participating.