The 2021 Nicholls Colonels baseball team represented Nicholls State University during the 2021 NCAA Division I baseball season.

The Colonels played their home games at Ben Meyer Diamond at Ray E. Didier Field and were led by eleventh–year head coach Seth Thibodeaux.

On June 2, 2021, following the conclusion of the 2021 season, Seth Thibodeaux resigned from his head coaching duties after amassing an overall record of 287–290 in his eleven seasons.

[2] The Southland Conference Coaches Poll was released on February 11, 2021, and the Colonels were picked to finish eighth in the conference with 108 votes.

[3] [4] Pitchers Catchers Infielders Outfielders *Rankings are based on the team's current ranking in the D1Baseball poll.