The 360 members of the House of Representatives are elected from single-seat constituencies using first-past-the-post voting; when vacancies occur, by-elections (or bye-elections) are called, scheduled, and administered by the Independent National Electoral Commission.

[3] In November 2020, the decision was upheld by a Court of Appeal which ordered INEC to hold a rerun election.

On February 9, 2021, Aba North/Aba South Representative Ossy Prestige (APGA) died from an undisclosed illness.

[7] Chimaobi Ebisike, the PDP nominee, defeated the APC's Mascot Uzor Kalu by 42% and over 6,600 votes.

[8] The election was marred by both extremely low turnout, at 3.29%, and violence with a bombing at the Umuola Hall polling station and the kidnapping of an APC collation officer.